VirusREvolution will interface and collaborate with other large, coordinated programs in virology, photonics, and bioinformatics.
CRC 1021 RNA Viruses is dedicated to studying RNA viruses, with a particular focus on their high mutation rates due to replication without proofreading, exploring fundamental aspects of RNA virus replication, and understanding how viral factors interact with cellular pathways to determine the pathogenicity of RNA viruses in humans and animals. This virological CRC will benefit from improved data analysis through VirusREvolution.
CRC 1076 AquaDiva seeks to explore the relationships between surface and subsurface biogeospheres, investigating how local geology and surface conditions impact the functional diversity and ecology of the subsurface microbiome, which is also significantly influenced by viral activities, akin to other aquatic habitats. This CRC will benefit from tools for virus discovery, annotation, and phylogenetic classification from VirusREvolution.
CRC 1129 Integrative Analysis of Pathogen Replication and Spread investigates pathogen-host interactions using advanced models and technologies to visualize events, quantify microbes at the single-cell level, manipulate pathogen and host factors, and establish new culture systems approximating physiological conditions.
CRC 1278 PolyTarget creates polymer-based nanoparticles for targeted anti-inflammatory and antiviral strategies, integrating a new project area focused on characterizing particle-cell interactions. VirusREvolution will support microscopy-based investigations for particle characterization during particle-host interactions and provide virus samples for further nanoparticle production. We expect to use the control samples and general chemical characterization tools made available within the CRC 1278.
GRK 2485 VIPER focuses on virus detection, pathogenesis, and intervention in animals. It aims to train the next-generation scientists in virus emergence (discovery, isolation, characterization, surveillance, and pathogenesis). This GRK 2485 will profit from the development of new tools in all these areas.
FOR 2830 Advanced Concepts in Cellular Immune Control of Cytomegalovirus focuses exclusively on cytomegaloviruses. Tools for automated annotation developed in CRC VirusREvolution will complement these projects.
CRC 1375 NOA addresses fundamental questions in nonlinear optics with respect to ultra-thin, nano-sized, or quantum materials. We see complementary aspects of knowledge exchange during tool development.
EXC 2051 Balance of the Microverse addresses questions regarding the dynamics of microbial balance at multiple levels. VirusREvolution complements EXC 2051 by adding viruses, which are important regulators of microbial communities, to the research focus.
ITN VIROINF focuses on the development of cross-disciplinary researchers by fostering virology-bioinformatics interactions. We will combine the knowledge of both consortia to focus on tool development for virus-host interactions.
FOR 5200 DEEP-DV investigates the early events of nuclear DNA virus infection to open up new possibilities to understand and ultimately control acute and chronic DNA virus infections. FOR 5200 DEEP-DV will develop bioinformatics tools for integrative analysis of multiomics data, such as single-cell RNA-seq, and scSLAM-seq, that do not overlap with VirusREvolution.
SPP 2330 New concepts in prokaryotic virus-host interactions uses intensive omics techniques to analyse phage-host interactions to discover fundamentally new concepts and mechanisms in virus organisation, unicellular and multicellular anti-viral defences, and viral impacts on microbial communities.
NFDI4Microbiota is to be the central hub in Germany for supporting the microbiology community with access to data, analysis services, data/metadata standards, and training. NFDI4Microbiota profits greatly from CRC VirusREvolution by the improvement of the virus database in project Z02.
BMBF Leibniz Center for Photonics in Infection Research will establish a user-friendly one-stop infrastructure for photonic and optical technologies. Fundamentally new solutions for the diagnosis, monitoring and therapy of infections will be researched and developed in order to transfer these solutions rapidly into routine application. VirusREvolution is working on basic technologies to form the unique technological infrastructure of LPI alongside state-of-the-art technologies.