To comprehensively characterize viruses, predict their pathogenic potential, and uncover virus tropism, there is a critical need for essential bioinformatic and photonic tools. Despite the recognised excellence of virology, bioinformatics, and photonics in Germany, these three fields have interacted only sporadically, with notable exceptions of HIV-1, Influenza A virus, and SARS-CoV-2. The primary objective of VirusREvolution is to lead the development of specialized bioinformatic and photonic tools dedicated to viruses. By bringing together the expertise of cutting-edge computational, photonic, and experimental researchers, we are laying the groundwork for significant breakthroughs achieved by systematically characterizing any newly emerging virus using tailored tools. We are convinced that only a continuous interaction of method development and application of the novel tools will accelerate virus research to be prepared for future outbreaks. The recruitment strategy of the last decade has made Friedrich Schiller University Jena and the adjacent research institutes the optimal location for VirusREvolution in Germany.